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张晓晓 / 副教授

个人简介

荷兰瓦赫宁根大学 硕士,德国卡塞尔大学 博士,美国明尼苏达大学医学院博士后, 2016年至南京农业大学工作。长期从事RNAi及microRNA研究。目前主要研究microRNA的生成机制,以及运用裸鼠和knock-out老鼠研究microRNA对疾病,尤其是对癌症的调控作用。此外还研究了microRNA对吗啡成瘾机制的调控。在Nucleic Acid Research, Blood, BBA等国际一流刊物上发表论文20多篇,并被Cell, Molecular Cell, PNAS等一流刊物引用。 联系方式:zhangxx@njau.edu.cn


教学情况

《动物学》


科研情况

Zhang, X., Graves, P., and Zeng, Y. (2013) Overexpression of human Argonaute2 inhibits cell and tumor growth.  Biochimica Biophysica Acta-General Subjects 1830: 2553–2561.  
Feng Y*, Zhang X*, Graves P, Zeng Y. (2012) A comprehensive analysis of precursor microRNA cleavage by human DicerRNA. RNA, 18(11):2083-92. doi: 10.1261/rna.033688.112. Epub 2012 Sep 14. * Contribute equally.   
Zhang, X., and Zeng, Y. (2011) Performing custom microRNA microarray experiments.  Journal of Visualized Experiments, doi: 10.3791/3250.  viewed>>50000
Feng, Y., Zhang X., Song, Q., Li, T., and Zeng, Y. (2011) Drosha processing controls the specificity and efficiency of global microRNA expression.  Biochimica Biophysica Acta, doi: 10.1016/j.bbagrm.2011.05.015.  
Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K., Blazar, B. R., Zeng, Y., and Zhou, Z. (2011) miR-221 and miR-155 regulate human dendritic cell development, apoptosis and IL-12 production through targeting of p27kip1, KPC1 and SOCS-1.  Blood 117: 4293-4303. 
Sanchez-Simon, FM., Zhang, X., Loh, HH., Law, PY., Rodriguez, RE. (2010) Morphine regulates dopaminergic neuron differentiation via miR-133b.  Mol Pharmacol. 78: 935-942. 
Ghosh, G., Subramanian, I. V., Adhikari, N., Zhang, X., Joshi, H. P., Basi, D. L., Chandrashekhar, Y. S., Hall, J. L., Roy, S., Zeng, Y., and Ramakrishnan, S. (2010) Hypoxia-induced microRNA-424 expression in endothelial cells regulates HIF-a isoforms by targeting CUL2 and promotes angiogenesis.  J. Clin. Invest. 120: 4141–4154.   
Park, C. W., Zeng, Y., Zhang, X., Subramanian, S., and Steer, C. J. (2010) Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells.  RNA Biology 7:606-614. PMID: 20864815.  
Castro, R. E., Ferreira, D. M. S., Zhang, X., Borralho, P. M., Sarver, A. L., Zeng, Y., Steer, C. J., Kren, B. T., and Rodrigues, C. M. P. (2010) Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.  American Journal of Physiology - Gastrointestinal and Liver Physiology 299: G887-897. 
Zhang, X., and Zeng, Y. (2010) The terminal loop region controls microRNA processing by Drosha and Dicer.  Nucl. Acids Res. 38: 7689-7697.  
Zhang, X., and Zeng, Y. (2010) Regulation of mammalian microRNA expression.  J. Cardiovascular Translational Res. 3: 197-203.   
Melkamu, T., Zhang, X., Tan, J., Zeng, Y., and Kassie, F. (2010) Alteration of microRNA expression in vinyl-carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 31: 252-258.  
Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H., and Law, P.-Y. (2009) μ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD.  Mol. Phar. 77: 102-109. 
Kren, B. T., Wong, P. Y.-P., Shiota, A., Zhang, X., Zeng, Y., and Steer, C. J. (2009) Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy.  Am J Physiol Gastrointest Liver Physiol 297: 1181-1192.  
Zhang, X., Graves, P. R., and Zeng, Y. (2009) Stable Argonaute2 overexpression differentially regulates microRNA production.  Biochimica Biophysica Acta  1789: 153-159. 
Zhang, X., Xu, W, Tan, J., and Zeng, Y. (2009) Stripping custom microRNA microarrays and the lessons learned about probe:slide interactions.  Anal. Biochem. 386: 222-227.  
Kren, B. T., Wong, P. Y.-P., Sarver, A., Zhang, X., Zeng, Y., and Steer, C. J. (2009) microRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis.  RNA Biol. 6: 65-72.   
Kalscheuer, S., Zhang, X., Upadhyaya, P., and Zeng, Y. (2008) Differential expression of microRNAs in early stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.  Carcinogenesis 29: 2394–2399.  
Zeng, Y., Sankala, H., Zhang, X., and Graves, P (2008) Phosphorylation of Argonaute2 at serine 387 facilitates its localization to processing bodies. Biochem. J. 413: 429-436  
Tan, J., Zhang, Y., Shen, Q., Zhang, X., and Xu, G. (2002) Effects of different NH4+/NO3—N ratios on water use efficiency and its biological characteristics of rice at early stage. Journal of Nanjing Agricultural University, 25(3): 49-52 (in Chinese).  
Zhang, X., Shen Q., Tan J, and Mao, Z. (2002) Effects of neem seed extracts on nitrogen use efficiency in two different soils. Ying Yong Sheng Tai Xue Bao. 13(11):1417-20 (in Chinese).