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冉婷婷 / 副教授


一、 主要学历及研究经历


2003.9-2007.7  南京农业大学生命科学学院,获理学学士学位
2007.9-2009.7  南京农业大学生命科学学院,获生化与分子生物学硕士学位
2009.9-2012.7  南京农业大学生命科学学院,获生化与分子生物学博士学位

2012.8-2014.12 讲师     南京农业大学生命科学学院微生物学系

2015.1-至今    副教授   南京农业大学生命科学学院微生物学系





    主要研究微生物来源的蛋白质的结构与功能,包括微生物来源的水解酶类,合成酶类及微生物来源的膜蛋白等。 已在Science,Acta Crystallogr D,Journal of Biological Chemistry, Biochemical Journal等杂志上发表SCI论文20篇。


中央高校基本科研业务费  KYZ201740 (主持)

国家自然科学基金青年基金  31400055  (主持)

江苏省自然科学基金青年基金  BK20140690 (主持)

南京农业大学青年科技创新基金 KJ2013027 (主持)

国家自然科学基金面上基金  31470095    (参与)  





Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism, Biochemical Journal (2018), 475, 2209–2224

Wang X#, Ran T#, Zhang X, Xin J, Zhang Z, Wu T, Wang W, Cai G*. 3.9 ? structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science. 2017 Dec 1;358(6367):1206-1209. doi: 10.1126/science.aan8414.(#共同一作)

Zhang X, Wu D, Guo T, Ran T, Wang W, Xu D*. Differential roles for ArcA and ArcB homologues in swarming motility in Serratia marcescens FS14. Antonie Van Leeuwenhoek. 2017 Nov 14. doi: 10.1007/s10482-017-0981-9.

Zhang Ya, Qiu Shenshen, Jia Shanshan, Xu Dongqing, Ran Tingting*, Wang Weiwu* Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14.  Proteins. 2017 Sep;85(9):1784-1790. doi: 10.1002/prot.25326.

Zhang F, Wei Q, Tong H, Xu D, Wang W, Ran T.* Crystal structure of MBP-PigG fusion protein and the essential function of PigG in the prodigiosin biosynthetic pathway in Serratia marcescens FS14.  International Journal of Biological Macromolecules.  99 (2017) 394–400

Xu Dongqing, Zhou Jiale, Lou Xiangdi, He Jianhua, Ran Tingting*, Wang Weiwu*.  Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism.  J Biol Chem. 2017 Mar 31;292(13):5195-5206. doi: 10.1074/jbc.M116.758110. Epub 2017 Feb 9.

Wei Q#Ran T#,Ma C,He J,Xu D,Wang W*.Crystal Structure and Function of PqqF in the Pyrroloquinoline Quinone Biosynthetic Pathway.J Biol Chem.  VOL. 291, NO. 30, pp. 15575–15587, July 22, 2016.

Ran T#, Ozorowski G#, Gao Y#, Sineshchekov O.A, Wang W*, Spudich J.L*, Luecke H* Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes. Acta Cryst. (2013). D69, 1965-1980 doi:10.1107/S0907444913017575 (封面文章,他引40次, IF 14.103)

Ran T, Gao Y, Marsh M, Zhu W, Wang M, Mao X, Xu L, Xu D*, Wang W*. Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for FAH family. Biochem J. 2013 Jan 1;449(1):51-60. (IF4.653)

Ran T, Gao M, Wei Q, He J, Tang L, Wang W, Xu D. Expression, crystallization and preliminary crystallographic data analysis of VioD, a hydroxylase in the violacein-biosynthesis pathway. Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):149-52.

Dongxia Wu, Pengpeng Li, Jiale Zhou, Meijing Gao, Xiangdi Lou, Tingting Ran, Shuwen Wu, Weiwu Wang, Dongqing Xu*, Identification of a toxic serralysin family protease with unique thermostable property from S. marcescens FS14, International Journal of Biological Macromolecules 93 (2016) 98–106

Wu D, Ran T, Wang W, Xu D*. Structure of a thermostable serralysin from Serratia sp. FS14 at 1.1 ? resolution. Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):10-5. doi: 10.1107/S2053230X15023092. Epub 2016 Jan 1.

Han N, Ran T, Lou X, Gao Y, He J, Tang L, Xu D* and Wang W*. Expression, crystallization and preliminary crystallographic data analysis of PigI, a putative L-prolyl-AMP ligase from the prodigiosin synthetic pathway in Serratia. Acta Cryst. (2014). F70, 624–627

Lou X#, Ran T#, Han N, Gao Y, He J, Tang L, Xu D*, Wang W*. Crystal structure of the catalytic domain of PigE: A transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14. Biochem Biophys Res Commun. 2014 Apr 25; 447(1):178-83. doi: 10.1016/j.bbrc.2014.03.125. Epub 2014 Apr 2.   

Zhou H, Li P, Wu D, Ran T, Wang W, Xu D. EheA from Exiguobacterium sp. yc3 is a novel thermostable DNase belonging to HNH endonuclease superfamily. FEMS Microbiol Lett. 2015 Dec;362(24).

Xu D, Gao Y, Wang P, Ran T, Wang W. Presence of an amino acid residue at position 619 required for the function of YidC in Rhodobacter sphaeroides.

Biochem Biophys Res Commun. 2015 Oct 16;466(2):267-71.


Li P, Kwok AH, Jiang J, Ran T, Xu D, Wang W, Leung FC. Comparative genome analyses of Serratia marcescens FS14 reveals its high antagonistic potential.  PLoS One. 2015 Apr 9;10(4):e0123061.


Zhu W, Lan Y, Lou X, Han N, Ran T, Xu L, Xu D, Wang WW*  Isolation of proteorhodopsin-bearing bacterium JL-3 from fresh water and characterization of the proteorhodopsin. FEMS Microbiol Lett. 2013 Jul;344(1):10-7. doi: 10.1111/1574-6968.12144.

 Liu S, Ran T, Shen X, Xu L, Wang W, Xu D* Expression, crystallization and preliminary crystallographic data analysis of PigF, an O-methyltransferase from the prodigiosin-synthetic pathway in Serratia. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug;68(Pt 8):898-901.

 Wang N, Wang M, Gao Y, Ran T, Lan Y, Wang J, Xu L*, Wang W*. Crystallization and preliminary X-ray crystallographic analysis of a blue-light-absorbing proteorhodopsin. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):281-3. Epub 2012 Feb 22.

 Ran T, Wang Y, Xu D*, Wang W*. Expression, purification, crystallization and preliminary crystallographic analysis of Cg1458: a novel oxaloacetate decarboxylase from Corynebacterium glutamicum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):968-70. Epub 2011 Jul 27.

齐立辉,郑新艳,冉婷婷,徐朗莱,王伟武*。 沙门氏菌草酰乙酸脱羧酶在大肠杆菌中的表达、纯化及其生化鉴定。 南京农业大学学报。2010,33( 4) : 81-86