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微生物学系

赵明文 教授
 
姓名:赵明文
职称:教授
联系电话:025-84395602
EMAIL:mwzhao@njau.edu.cn
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赵明文,男,1974年6月出生, 2003年毕业于南京农业大学生命科学学院微生物学系,获得理学博士学位。现任南京农业大学生命科学学院教授,博士生导师,并担任中国食用菌协会理事,中国农学会食用菌分会理事,中国菌物学会药用真菌专业委员会委员。入选江苏省人事厅“333工程”优秀中青年学术带头人培养计划和江苏省教育厅“青蓝工程”优秀中青年学术骨干教师。主要从事食药用真菌的遗传育种和食用菌工厂化栽培相关的研究工作。主持国家自然科学基金4项,江苏省自然科学基金创新人才项目1项,江苏省农业科技支撑项目1项,上海市农委重点攻关项目子项目3项,南京农业大学青年基金1项。以第一作者和通讯作者发表相关论文30多篇,其中SCI论文20多篇,论著2部,参与获得上海市科技进步二等奖1项。

主持的项目有:

国家自然科学基金:《灵芝鲨烯单加氧酶基因的克隆及其特性研究》,编号:30300006,2004.01-2006.12

国家自然科学基金:《灵芝鲨烯合酶基因转录调控元件的克隆及其与转录因子结合特性分析》,编号:30571294,2006.01-2008.12

国家自然科学基金:《茉莉酸甲酯对灵芝三萜生物合成基因的转录调控作用及调控机理研究》,编号:30871767,2009.01-2009.12

国家自然科学基金:《灵芝三萜生物合成调控网络中关键基因的克隆及其对茉莉酸甲酯响应机理的研究》,编号:30970042,2010.01-2012.12

国家科技支撑项目子项目:《珍稀真菌高值利用技术研究与产品开发》,编号:2012BAD36B05,2012年1月-2015年12月。

国家科技支撑项目子项目:《食用菌新品种培育及制种关键技术研究》,编号:2013BAD16B02,2013年1月-2016年12月。

国家科技支撑项目子项目:《长三角现代农业区大学农业科技服务模式关键技术集成与示范》,编号:2013BAD20B05,2013年1月-2016年12月。

江苏省自然科学基金创新人才项目:《灵芝法呢酯焦磷合酶基因的克隆及其在灵芝酸生物合成中调控作用的研究》,BK2006517,2006-2008

江苏省农业科技支撑项目:《高三萜灵芝菌种的选育及其生物学特性的研究》,编号:BE2011312,2011年7月-2014年6月。

上海市农委重点攻关项目子项目:《食用菌稳定性生产关键技术研究与示范》,编号:农科攻字(2008)第8-1号,起止日期:2008.9-2011.8

 

近期发表的论文: 

 2015

1)  Li M. J., T. X. Chen, T. Gao, Z. G. Miao, A. L. Jiang, L. Shi, A. Ren, M. W. Zhao*,  UDP-glucose pyrophosphorylase influences polysaccharide synthesis, cell wall components, and hyphal branching in Ganoderma lucidum via regulation of the balance between glucose-1-phosphate and UDP-glucose, Fungal Genetics and Biology, 2015, 82: 251-263, *corresponding author
2)  Li C. Y§., L. Shi§; D. D. Chen, A. Ren, T. Gao, M. W. Zhao*, Functional analysis of the role of glutathione peroxidase (GPx) in the ROS signaling pathway, hyphal branching and regulation of ganoderic acid biosynthesis in Ganoderma lucidum, Fungal Genetics and Biology, 2015, 82: 168-180, *corresponding author
3)  Shi L., L. Gong, X. Y. Zhang, A. Ren, T. Gao, M. W. Zhao*, Induced effect of Methyl Jasmonate on hyphal growth and secondary metabolism of Ganoderma lucidum partly via ROS generated by NADPH oxidase, Fungal Genetics and Biology, 2015, 81: 201-211, *corresponding author
4)  Han Q.§, F. L. Wu§, X. N. Wang, H. Qi, L. Shi, A. Ren, Q. H. Liu, M. W. Zhao*and C. M. Tang*, The bacterial lipopeptide iturins induce Verticillium dahliae cell death by affecting fungal signaling pathways and mediate plant defence responses involved in pathogen-associated molecular pattern-triggered immunity, Environmental Microbiology, 2015, 17(4), 1166–1188 *corresponding author
5)  Ren J.§, Y. Sang§, J. J. Ni, J. Tao, J. Lu, M. W. Zhao*, Y. F. Yao*, Acetylation Regulates Survival of Salmonella enterica Serovar Typhimurium under Acid Stress, Applied and Environmental Microbiology, 2015, 81:5675–5682 *corresponding author
6)  Mu D. S., C. Y. Li, L. Shi, X. C. Zhang, A. Ren, M. W. Zhao*, Bioinformatic identification of potential microRNAs and their targets in Ganoderma lucidum,International Journal of Medicinal Mushrooms, 2015, accepted, *corresponding author
 
 
2014
7)  Mu D. S., C. Y. Li, X. C. Zhang, X. B. Li, L. Shi, A. Ren, and M. W. Zhao*, Functions of the nicotinamide adenine dinucleotide phosphate oxidase family in Ganoderma lucidum: an essential role in ganoderic acid biosynthesis regulation, hyphal branching, fruiting body development, and oxidative-stress resistance, Environmental Microbiology, 2014, 16(6), 1709–1728, *corresponding author
8)  Ren A., X. B. Li, Z. G. Miao, L. Shi, A. L. Jaing, M. W. Zhao*, Transcript and metabolite alterations increase ganoderic acid content in Ganoderma lucidum using acetic acid as an inducer, Biotechnology Letters, 2014, 36:2529–2536  *corresponding author
 
2013
9)  Ren A.§, M. J. Li§, L. Shi, D. S. Mu, A. L. Jiang, Q. Han, M. W. Zhao*, Profiling and quantifying differential gene transcription provide insights into ganoderic acid biosynthesis in Ganoderma lucidum in response to methyl jasmonate, PLoS ONE, 2013, 8(6): e65027 *corresponding author
10) Ren A., X. Ouyang, L. Shi, A. L. Jiang, D. S. Mu, M. J. Li, Q. Han, M. W. Zhao*, Molecular characterization and expression analysis of GlHMGS, a gene encoding hydroxymethylglutaryl-CoA synthase from Ganoderma lucidum (Ling-zhi) in ganoderic acid biosynthesis pathway, World Journal of Microbiology and Biotechnology, 2013,29: 523-531, *corresponding author
11) Fang X., L. Shi, A. Ren, A. L. Jiang, F. L. Wu , M. W. Zhao*, The cloning, characterization and functional analysis of a gene encoding an acetyl-CoA acetyltransferase involved in triterpene biosynthesis in Ganoderma lucidum, Mycoscience, 2013, 54: 100-105 *corresponding author
12) Wu F. L.§, L. Shi,§ J. Yao, A. Ren, C. Zhou, D. S. Mu, M. W. Zhao*, The cloning, characterization, and functional analysis of a gene encoding an isopentenyl diphosphate isomerase involved in triterpene biosynthesis in the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes ), International Journal of Medicinal Mushrooms, 2013, 15(3): 223–232 *corresponding author
 
2012
13) Mu D. S., L. Shi, A. Ren, M. J. Li, F. L. Wu, A L Jiang, M. W. Zhao*,The development and application of a multiple gene co-silencing system using endogenous URA3 as a reporter gene in Ganoderma lucidumPLoS ONE, 2012,7(8): e43737 *corresponding author
14) Li C.H., L. Shi, Q. Han, H. L. Hu, M. W. Zhao*,C. M. Tang*, S. P. Li, Biocontrol of verticillium wilt and colonization of cotton plants by an endophytic bacterial isolate, Journal of Applied Microbiology, 2012, 113: 641--651   *corresponding author
15) Shi. L., X. Fang, M. J. Li, D. S. Mu, A. Ren, Q. Tan, M. W. Zhao*, Development of a simple and efficient transformation system for the basidiomycetous medicinal fungus Ganoderma lucidum, World Journal of Microbiology and Biotechnology, 2012, 28:283–291, *corresponding author
16) Shi. L., L. Qin, Y. J. Xu, A. Ren, X. Fang, D. S. Mu, Q. Tan, M. W. Zhao*,  Molecular cloning, characterization, and function analysis of a mevalonate pyrophosphate decarbroxylase gene from Ganoderma lucidum, Molecular Biology Report, 2012, 39:6149–6159, *corresponding author
 
2011
17) Xue Q., J. Sun, M. W. Zhao*, K. Y. Zhang, R. Lai, Immunostimulatory and anti-tumor activity of a water-soluble polysaccharide from Phellinus baumii mycelia,World Journal of Microbiology and Biotechnology, 2011, 27:1017–1023 , *corresponding author
 
2010
18) Shi L., A. Ren, D. S. Mu, M. W. Zhao*, Current progress in the study on biosynthesis and regulation of ganoderic acids, Applied Microbiology and Biotechnology, 2010, 88:143-1251   *corresponding author 
19) Ren A., L. Qin, L. Shi, X. Dong, D. S. Mu, Y. X. Li, M. W. Zhao*, Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum, Bioresource Technology, 2010, 101:6785-6790 *corresponding author 
20) Shang C. H., L. Shi, A. Ren, L. Qin, M. W. Zhao*, Molecular cloning characterization, and differential expression of a lanosterol synthase gene from the Ganoderma lucidum, Bioscience Biotechnology and Biochemistry, 2010, 74(5):974-978  *corresponding author 
21) Li C. H., M. W. Zhao*, C. M. Tang*, S. P. Li, Population dynamics and identification of endophytic bacteria antagonistic toward plant-pathogenic fungi in cotton root, Microbial Ecology, 2010, 59:344-356 *corresponding author  
 
2009以前
22) Xue Q., Y. X. Ding, C. H. Shang, C. Jiang, M. W. Zhao*, Functional expression of LZ-8, a fungal immunomodulatory protein from Ganoderma lucidum in Pichia pastoris, Journal of General and Applied Microbiology 2008, 54(6), 385-392 *corresponding author 
23) Shang C. H., F. Zhu, N. Li, X. Ou-Yang, L. Shi, M.W. Zhao*, Y. X. Li, Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast, Bioscience Biotechnology and Biochemistry, 2008, 72(5):1333-1339 *corresponding author    
24) Ding Y. X., X. Ou-Yang, C. H. Shang, A. Ren, L. Shi, Y. X. Li, M.W. Zhao*, Molecular cloning, characterization, and differential expression of a farnesyl-diphosphate synthase gene from the basidiomycetous fungus Ganoderma lucidum, Bioscience Biotechnology and Biochemistry, 2008, 72(6): 1571-1579 *corresponding author    
25) Zhao M.W., W.Q. Liang, D.B. Zhang, N. Wang, C. G. Wang, Y. J. Pan, Cloning and characterization of the squalene synthase (SQS) gene from Ganoderma lucidum, Journal of Microbiology and Biotechnology, 2007, 17(7):1106-1112   
26) Li N, X. H. Liu, J. Zhou, Y. X. Li, M. W. Zhao*, Analysis of influence of environmental conditions on ganoderic acid content in Ganoderma lucidum using orthogonal design, Journal of Microbiology and Biotechnology, 2006, 16(12): 1940-1946. *corresponding author  
27) Xu F., M.W. Zhao*, Y. X. Li, Cloning and sequence analysis of a glyceraldehyde-3-phosphate dehydrogenase gene from Ganoderma lucidum, The Journal of Microbiology, 2006, 44(5): 515-522 *corresponding author  
28) Zhao M.W., J.Y. Zhong, W.Q. Liang, N. Wang, M. J. Chen, D.B. Zhang, Y. J. Pan, S.C. Jong, Analysis of squalene synthase expression during the development of Ganoderma lucidumJournal of Microbiology and Biotechnology, 2004, 14(1): 116-120
29) 李玉祥、赵明文编著,《名特优食用菌栽培技术》,江西科学技术出版社,2002
30) 李玉祥、赵明文、王南编著,《无公害食用菌生产技术》,云南科技出版社,2002
 
 
获奖情况:
1、《食用菌工业化生产关键技术与应用》;上海市科学技术奖二等奖;排名第六;2008.12
2、《青蓝工程优秀骨干教师》;江苏省教育厅;2006
3、江苏省“333工程”第三层次培养对象;2011
 
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