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微生物学系

朱军 教授
 
姓名:朱军
职称:教授
联系电话:025-84396645
EMAIL:jun_zhu@njau.edu.cn
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研究方向:

1、分子微生物学与生物固氮

2、病原细菌致病机理

发表SCI 的论文(按时间):
1. Chang, C. H., J. Zhu, and S.C. Winans. 1996. Pleiotropic phenotypes caused by genetic ablation of the receiver module of the Agrobacterium tumefaciens VirA protein. J Bacteriol. 178:4710-4716.
2. Zhu, J. and S. C. Winans. 1998. Activity of the quorum-sensing regulator TraR of Agrobacterium tumefaciens is inhibited by a truncated, dominant defective TraR-like protein. Mol. Microbiol.27:289-297.
3. Zhu, J., J. W. Beaber, M.I. More, C. Fuqua, A. Eberhard, and S.C. Winans. 1998. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens. J Bacteriol. 180:5398-5405.
4. Kalogeraki, V. S., J. Zhu, A. Eberhard, E.L. Madsen, and S.C. Winans. 1999. The phenolic vir gene inducer ferulic acid is O-demethylated by the VirH2 protein of an Agrobacterium tumefaciens Ti plasmid. Mol. Microbiol. 34:512-522.
5. Zhu, J. and S. C. Winans. 1999. Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells. Proc.Natl. Acad. Sci USA. 96: 4832-4837
6. Kalogeraki, V. S., J. Zhu, J. L. Stryker, and S.C. Winans. 2000. The right end of the vir region of an octopine-type Ti plasmid contains four new members of the vir regulon that are not essential for pathogenesis. J Bacteriol. 182:1774-1778
7. Zhu, J., P.M. Oger, B. Schrammeijer, P.J. Hooykaas, S.K. Farrand, and S. C. Winans. 2000. The bases of crown gall tumorigenesis. J Bacteriol. 182:3885-3895.
8. Chai, Y., J. Zhu, and S.C. Winans. 2001. TrlR, a defective TraR-like protein of Agrobacterium tumefaciens, blocks TraR function in vitro by forming inactive TrlR:TraR dimers. Mol. Microbiol. 40:414-421.
9. Swiderska, A., A.K. Berndtson, M.R. Cha, L. Li, G. M. Beaudoin, J. Zhu, and C. Fuqua. 2001. Inhibition of the Agrobacterium tumefaciens TraR quorum-sensing regulator. Interactions with the TraM anti-activator. J Biol. Chem. 276:49449-49458.
10. Zhu, J. and S. C. Winans. 2001.The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization. Proc. Natl. Acad.Sci. USA. 98: 1507-1512.
13. Zhu, J., M.B. Miller, R.E. Vance, M. Dziejman, B.L. Bassler, and J.J. Mekalanos. 2002. Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc. Natl. Acad. Sci. USA. 99:3129-3134.
14. Bina, J., J. Zhu, M. Dziejman, S. Faruque, S. Calderwood, and J.J. Mekalanos. 2003.ToxR Regulon of Vibrio cholerae and Its Expression in Vibrios Shed by Cholera Patients. Proc. Natl. Acad. Sci. USA. 100:2801-2806. [Co-first author]
15. Vance, R.E., J. Zhu, and J.J. Mekalanos. 2003. A constitutively active mutant of the quorum-sensing regulator LuxO affects a protease production and biofilm formation in Vibrio cholerae. Infect. Immunity 71:2571-2576.
16. Faruque, S.M., J. Zhu, Asadulghani, M. Kamruzzaman. and J.J. Mekalanos. 2003. Examination of diverse TCP-positive Vibrio cholerae strains fails to demonstrate evidence for VPI phage. Infect. Immunity 71:2993-2999.
17. Zhu, J., Y. Chai, Z. Zhong, S. Li, and S.C. Winans. 2003. An Agrobacterium Bioassay strain for Ultrasensitive Detection of N-Acylhomoserine Lactone-Type Quorum-Sensing Molecules: Detection of Autoinducers in Mesorhizobium huakuii. Appl. Environ. Microbiol. 69:6949-6953. (Corresponding author)
18. Zhu, J. and J. J. Mekalanos. 2003. Quorum sensing-regulated biofilms enhance colonization in Vibrio cholerae. Dev. Cell 5:647-656.
19. Wang, H., Z. Zhong, T. Cai, S. Li, and J. Zhu. 2004. Heterologous overexpression of quorum-sensing regulators to study cell-density-dependent phenotypes in a symbiotic plant bacterium Mesorhizobium huakuii. Arch. Microbiol. 182:520-525. (Corresponding author)
20. Lenz, D. H., M. B. Miller, J. Zhu, R. V. Kulkarni, and B. L. Bassler. 2005. CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae. Mol. Microbiol. 58:1186-1202.
21. Hung, T., J. Zhu, D. Sturtevant, and J.J. Mekalanos. 2006. Bile acids stimulate biofilm formation in Vibrio cholerae. Mol. Microbiol. 59:193-201.
22. Joelsson, A., Z. Liu, and J. Zhu. 2006. Genetic and phenotypic diversity of quorum sensing systems in clinical and environmental isolates of Vibrio cholerae. Infect. Immunity 74:1141-1147.(Corresponding author)
23. Zheng H, Z. Zhong, X. Lai, WX. Chen, S. Li, and J. Zhu. 2006. A LuxR/LuxI-Type Quorum-Sensing System in a Plant Bacterium, Mesorhizobium tianshanense, Controls Symbiotic Nodulation. J Bacteriol. 188:1943-1949. (Corresponding author)
24. Liu, Z., A. Hsiao, A. Joelsson, and J. Zhu. 2006. A transcriptional regulator VqmA increases the expression of the quorum sensing activator HapR in Vibrio cholerae. J. Bacteriol.188:2146-2153. (Corresponding author)
25. Vaitkevicius,K., B. Lindmark, G. Ou, T. Song, C. Toma, Masaak, Iwanaga, J. Zhu, A.Andersson, M.Hammarstrom, S. Tuck, and S. N. Wai. 2006. A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing.Proc. Natl. Acad. Sci. USA. 103:9280-9285.
26. Hsiao, A., Z. Liu, A. Joelsson, and J. Zhu. 2006. Vibrio cholerae virulence regulator-coordinated evasion of host immunity. Proc. Natl. Acad. Sci. USA. 103:14542-14547.(Corresponding author)
27. Wang, H., T. Cai, M. Weng, J. Zhou, H. Cao, Z. Zhong, and J. Zhu. 2006. Conditional Production of Acyl Homoserine Lactone-Type Quorum-Sensing Signals in Clinical Isolates of Enterobacteria. J Med. Microbiol. 55: 1751-1753. (Corresponding author)
28. Liu, Z., Stirling, F. and J. Zhu. Temporal quorum sensing induction regulates Vibrio cholerae biofilm architectures. Infect. Immunity. 75:122-126 (Corresponding author)

承担科研项目情况
1、国家杰出青年基金,30325004,朱军(主持人), ¥1,200,000
01/01/04-12/31/07
微生物生理及生物化学
2、教育部重大项目,306009, 朱军(主持人),¥400,000
01/01/06-12/31/08
细菌群体感应在病原微生物及化学毒剂防治中作用机理及特效防治方法的研究
3、国家自然基金面上项目,30570011,朱军(主持人),¥250,000
01/01/06-12/31/08
群体感应在天山根瘤菌菌植互作过程中的调节作用
4、霍英东教育基金AHLs 高效检测菌株构建及在根瘤菌结瘤过程研究中的应用
(91023)教育部 1.7 万美元 主持 2004-2005

 

 
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